Research Scientist, Multiple Myeloma - Translational Medicine

Research Scientist, Multiple Myeloma - Translational MedicineJob Description For Current Kite Pharma Employees and Contractors: We're here for one reason and one reason only – to cure cancer. Every moment is dedicated to developing treatments and every action moves us one step closer to our goal. We've made incredible scientific breakthroughs and our pioneering personalized CAR T-cell therapies have changed the paradigm. But we're not finished yet.
Join Kite, as we make even bigger advances in cancer therapies, and help shape where our business and medical science goes next.
We believe every employee deserves a great leader. People Leaders are the cornerstone to the employee experience at Gilead and Kite. As a people leader now or in the future, you are the key driver in evolving our culture and creating an environment where every employee feels included, developed and empowered to fulfil their aspirations. Join Kite and help create more tomorrows.

Job DescriptionThe Research Scientist will design and execute biomarker and translational strategy for the clinical development of Kite's chimeric antigen receptor (CAR-T) programs in Multiple Myeloma. As a member of the Translational Medicine Clinical Pharmacology team, you will be at the intersection of Research and Clinical Development, providing valuable insight into the function of CAR-T cells in patients and the development of potential prognostic tools. You will facilitate clinical trial execution, synthesize scientific data, communicate key findings cross-functionally.
Job Responsibilities Directs and establishes pharmacokinetic and pharmacodynamic (PK/PD) analysis to support clinical pharmacology for CAR T clinical trials in Multiple MyelomaServes as Biomarker lead on clinical study teams to oversee delivery of pharmacology data and documentation required for pivotal and registrational study filingsReviews and contributes to clinical protocol design and study activitiesIdentifies and establishes agreements with contract research organizations (CRO) and support the transfer of novel methodsCollaborates with Clinical development teams including Clinical Operations, Regulatory, Clinical Data Management and Biometrics/Stats to advance data acquisition and analyses of clinical trial dataGuides the resolution of clinical pharmacology/translational queries from regulatory agencies, supports writing and reviewing responses to regulatory queries.Supports the preparation of data packages for publication with medical writers, presentation and/or submission to regulatory agenciesCollaborates with Bioinformatics and Statistical teams for exploratory biomarker correlative studies and deeper analysis of tumor biology and CAR T functionalityContributes to external scientific discussions/research collaborations and publications and engagement with key opinion leaders in the fieldBasic Qualifications Doctorate and 2+ years of scientific experience
OR
Master's and 6+ years of scientific experience
OR
Bachelor's and 8+ years of scientific experience
Preferred Qualifications Familiarity and experience with clinical and biomarker operationsPrior experience in Regulatory filingsDeep background in cancer immunotherapy, immunology and/or oncology with experience focusing on Multiple MyelomaIn-depth understanding of multiple myeloma, knowledge of clinical landscape, evolving therapy, competitive scenariosExcellent understanding of clinical, translational, and mechanistic dataUnderstanding of early or late-stage drug and translational development process; including clinical trial experience in industry or academiaFamiliarity with bioanalytical assay development and validation in a GxP environmentExperience working with engineered T cells, immunophenotyping, and NGS-based approaches to profile the function of tumor and immune cellsComfortable in a matrixed and fast-paced company environment and able to adapt to changing prioritiesMeaningful collaboration, excellent interpersonal and communication skillsProficient with data presentations to communicate to a diverse cross-functional audienceMaintain a high degree of accuracy and attention to detailPh.D. degree in biology-related field (immunology, cancer biology, bioinformatics or a closely related field)The work you do at Kite will help change how cancer is treated and ensure patients and their families have more time together. Ready to create more tomorrows with us? Hit apply.
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The salary range for this position is: $150,535.00 - $194,810.00. Kite considers a variety of factors when determining base compensation, including experience, qualifications, and geographic location. These considerations mean actual compensation will vary. This position may also be eligible for a discretionary annual bonus, discretionary stock-based long-term incentives (eligibility may vary based on role), paid time off, and a benefits package. Benefits include company-sponsored medical, dental, vision, and life insurance plans*. Job Description For Current Kite Pharma Employees and Contractors: Please log onto your Internal Career Site to apply for this job.
We're here for one reason and one reason only – to cure cancer. Every moment is dedicated to developing treatments and every action moves us one step closer to our goal. We've made incredible scientific breakthroughs and our pioneering personalized CAR T-cell therapies have changed the paradigm. But we're not finished yet.
Join Kite, as we make even bigger advances in cancer therapies, and help shape where our business and medical science goes next.
We believe every employee deserves a great leader. People Leaders are the cornerstone to the employee experience at Gilead and Kite. As a people leader now or in the future, you are the key driver in evolving our culture and creating an environment where every employee feels included, developed and empowered to fulfil their aspirations. Join Kite and help create more tomorrows.

Job DescriptionThe Research Scientist will design and execute biomarker and translational strategy for the clinical development of Kite's chimeric antigen receptor (CAR-T) programs in Multiple Myeloma. As a member of the Translational Medicine Clinical Pharmacology team, you will be at the intersection of Research and Clinical Development, providing valuable insight into the function of CAR-T cells in patients and the development of potential prognostic tools. You will facilitate clinical trial execution, synthesize scientific data, communicate key findings cross-functionally.
Job Responsibilities Directs and establishes pharmacokinetic and pharmacodynamic (PK/PD) analysis to support clinical pharmacology for CAR T clinical trials in Multiple MyelomaServes as Biomarker lead on clinical study teams to oversee delivery of pharmacology data and documentation required for pivotal and registrational study filingsReviews and contributes to clinical protocol design and study activitiesIdentifies and establishes agreements with contract research organizations (CRO) and support the transfer of novel methodsCollaborates with Clinical development teams including Clinical Operations, Regulatory, Clinical Data Management and Biometrics/Stats to advance data acquisition and analyses of clinical trial dataGuides the resolution of clinical pharmacology/translational queries from regulatory agencies, supports writing and reviewing responses to regulatory queries.Supports the preparation of data packages for publication with medical writers, presentation and/or submission to regulatory agenciesCollaborates with Bioinformatics and Statistical teams for exploratory biomarker correlative studies and deeper analysis of tumor biology and CAR T functionalityContributes to external scientific discussions/research collaborations and publications and engagement with key opinion leaders in the fieldBasic Qualifications Doctorate and 2+ years of scientific experience
OR
Master's and 6+ years of scientific experience
OR
Bachelor's and 8+ years of scientific experience
Preferred Qualifications Familiarity and experience with clinical and biomarker operationsPrior experience in Regulatory filingsDeep background in cancer immunotherapy, immunology and/or oncology with experience focusing on Multiple MyelomaIn-depth understanding of multiple myeloma, knowledge of clinical landscape, evolving therapy, competitive scenariosExcellent understanding of clinical, translational, and mechanistic dataUnderstanding of early or late-stage drug and translational development process; including clinical trial experience in industry or academiaFamiliarity with bioanalytical assay development and validation in a GxP environmentExperience working with engineered T cells, immunophenotyping, and NGS-based approaches to profile the function of tumor and immune cellsComfortable in a matrixed and fast-paced company environment and able to adapt to changing prioritiesMeaningful collaboration, excellent interpersonal and communication skillsProficient with data presentations to communicate to a diverse cross-functional audienceMaintain a high degree of accuracy and attention to detailPh.D. degree in biology-related field (immunology, cancer biology, bioinformatics or a closely related field)The work you do at Kite will help change how cancer is treated and ensure patients and their families have more time together. Ready to create more tomorrows with us? Hit apply.
#LI-ML1
#IND123
The salary range for this position is: $150,535.00 - $194,810.00. Kite considers a variety of factors when determining base compensation, including experience, qualifications, and geographic location. These considerations mean actual compensation will vary. This position may also be eligible for a discretionary annual bonus, discretionary stock-based long-term incentives (eligibility may vary based on role), paid time off, and a benefits package. Benefits include company-sponsored medical, dental, vision, and life insurance plans*. For additional benefits information, visit:
https://www.gilead.com/careers/compensation-benefits-and-wellbeing
* Eligible employees may participate in benefit plans, subject to the terms and conditions of the applicable plans.

Kite is a biopharmaceutical company engaged in the development of innovative cancer immunotherapies with a goal of providing rapid, long-term durable response and eliminating the burden of chronic care. The company is focused on chimeric antigen receptor (CAR) and T cell receptor (TCR) engineered cell therapies designed to empower the immune system's ability to recognize and kill tumors. Kite is based in Santa Monica, CA. For more information on Kite, please visit www.kitepharma.com . Sign up to follow @KitePharma on Twitter at www.twitter.com/kitepharma .

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For Current Kite Pharma Employees and Contractors: Please log onto your Internal Career Site to apply for this job.

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