The Institute for Protein Innovation (IPI)is a nonprofit research organization advancing protein science to accelerate research and improve human health. Founded in 2017 and located in Boston's Longwood Medical Area, the Institute's three-pronged strategy is to build protein tools, conduct related internal research and develop educational programs for the protein science and biological research communities. With a significant endowment, IPI uniquely combines the freedom of academia with the high throughput and scale of industry to take on transformative projects. IPI has built a robust platform for discovering, developing, and distributing synthetic antibodies and other protein tools to share with the biomedical community. The Institute's deep protein expertise, collaborative spirit and research tools are powering new biomedical and therapeutic discoveries with a growing community of researchers at Harvard Medical School, Boston Children's Hospital and other institutions across Greater Boston and beyond. Overview The Antibody Characterization & Validation Scientist plays an essential role in the establishment and running of high-throughput assays to test antibodies for activity in various imaging applications. Having completed a doctorate in a biological field, the Scientist will bring experience in high content imaging and automated data analysis to the Team. The Scientist must be adept in quality control and process management and reliably provide detailed documentation on experiments completed. The Scientist will work in close collaboration with other scientific team members and contribute to a wide array of antibody characterization and assay application projects. This position is highly collaborative and strong communication skills are essential. Primary Responsibilities ·Establish immunofluorescence (IF) methods and workflows to assess reagent antibody activity in cell lines and primary cells. ·Maintain cell lines and primary cell cultures. ·Build infrastructure for image analysis, data handling, and result dissemination. ·Leverage robotics and automation for high throughput antibody analysis. ·Troubleshoot technical problems. ·Prepare internal reports, presentations and peer reviewed scientific publications. ·Attend cross functional team meetings and be the subject matter expert on imaging applications and data. ·Supervise research associates and coordinate with other scientists to ensure efficient, high-quality antibody testing. Qualifications ·PhD degree and postdoc in a life science field (i.e., biology, protein biochemistry, or structural biology) ·Extensive experience in IF and automated image analysis. ·Proficiency with mammalian cell culture. ·Familiarity with assays utilized to assess reagent antibody activity (Western Blotting, IP, ELISA, Flow Cytometry) is preferred. ·Experience with liquid handling robots and automation will be a plus. ·Experience with ICC and IHC will be beneficial. ·Ability to work in a fast-paced, intellectually challenging environment ·Good organizational and documentation skills ·Strong verbal and written communication skills ·Enthusiastic team member with a strong commitment to mission and a desire to conduct impactful science IPI provides competitive compensation and an excellent benefits package to support physical, mental and financial health. Highlights of benefits include: ·100% employer-paid medical, dental, and vision plans ·Flexible spending accountsand a healthcare reimbursement account ·401(k) plan with generous 6% employer match – immediately 100% vested ·Generous PTO package ·Commuter and parking reimbursement ·Career development opportunities For more information, visit proteininnovation.org or follow us on social media, @ipiproteins. IPI is an independent 501(c)(3) nonprofit research organization and an equal-opportunity employer. The Institute celebrates diversity and is committed to creating an inclusive environment for all employees. Please be advised that you will be required to provide evidence of your identity and eligibility for employment in the United States. IPI will not guarantee sponsorship of foreign nationals and retains complete discretion regarding providing sponsorship to any prospective or existing employee at time of hire or at any time in the future.
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