SENIOR SCIENTIST BIOTHERAPEUTICSIncendia Therapeutics is a precision oncology company dedicated to reprogramming the tumor microenvironment with the express intent of bringing recalcitrant cancers into submission. We recognize that cancer cells create a hostile microenvironment to privilege their own survival at the expense of the host tissue. Incendia's approach is to attack the structural and biochemical underpinnings of the tumor microenvironment to enable host immune cells and therapeutics to reach the tumor.
Our mission is to serve cancer patients who are the most in need of novel therapeutics. Everything we do is guided by caring for and doing the right thing for those patients. The Company's most advanced clinical program is a clinical trial evaluating safety and potential efficacy of PRTH-101 in patients with advanced solid tumors (NCT05753722). Visit www.incendiatx.com to learn more.
LOCATIONCambridge, MA
DESCRIPTIONIncendia Therapeutics is seeking an exceptional and highly motivated Senior Scientist to join the Biotherapeutics Drug Discovery group. The successful applicant will support therapeutic antibody discovery and optimization campaigns – including leading reagent generation strategies, developing antibody campaign workplans and screening funnels, overseeing the execution of the campaigns through CRO partners, and optimizing lead antibodies for development candidate selection.
RESPONSIBILITIESReporting to the Director, Biotherapeutics the Senior Scientist will be part of the Biotherapeutics Drug Discovery team. Here's What You'll Do: Collaborate with project teams to identify and generate key reagents needed for target validation and antibody campaigns including proteins, antibodies, and engineered cell lines.Interface with CRO antibody partners to execute antibody discovery, humanization, and optimization campaigns.Oversee CROs to produce recombinant proteins and antibodies for in vitro screening and scale-up for in vivo studies, manage in-house inventory, help build LIMS and lab as company grows.Collaborate with project teams to support Development Candidate nomination, including developing screening funnels and assays to support hit-to-lead identification.Develop and implement analytical methods to support Biophysical assessment, including affinity measurements, and Developability characterization.Help build structural modeling capabilities for rational design optimization.REQUIREMENTS & QUALIFICATIONSDegree in Biochemistry, Molecular/Cellular Biology, or a related field + indicated years of industry experience:Ph.D. + 1-3 yrs – orM.S. + 8-10 yrs – orB.S. +10-12 yrsExperience with multiple antibody discovery platforms including in vivo immunization and in vitro display approaches.Knowledge of antibody engineering: humanization, affinity maturation, sequence analysis & optimization.Experience developing & implementing high-throughput screening assays including, ELISA, cell-based binding FACS, reporter cell lines, HTRF, AlphaLISA.Direct experience with development of therapeutic antibodies.CRO management experience.Experience within silico tools for developability screening, antibody engineering, LIMS.Excellent verbal and written communication and interpersonal skills for participating across functional groups and externally.Demonstrated commitment to quality, attention to detail, and team player mentality.Demonstrated ability to think critically and creatively as part of a fast-paced research team.Preferred Qualifications:Knowledge of protein structure and modeling to enable rational design & lead optimization.Knowledge of techniques and instrumentation related to protein characterization and analytics (SPR/BLI binding, LC/MS, peptide mapping, PTM characterization, HPLC, DSC, DLS, etc.).Understanding of cell line development and CMC activities.BenefitsCompetitive salary and benefits package.Opportunity for professional development and career advancement.A supportive and innovative work environment.Access to cutting-edge technology and research tool.At Incendia we strive to build a diverse and equitable workplace
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