Sr. Research Associate

614191
Our client, a leading Medical Biotechnology company in Alameda, CA , is looking for a Sr. Research Associate to to develop formulations for its CRISPR by Design™ platform. The ideal candidate should have a good understanding of lipid nanoparticle formulations by various mixing and downstream processing techniques.
Skills:
BS with 5+ years of experience, or MS/PhD with 3+ year of experience in an industry setting. Degree in Chemistry, Biochemistry, Chemical Engineering, Bioengineering, Pharmaceutical Sciences, or related discipline.3-5 years of real industry experience, AAV, Viral Vector, MRNA, solid lab analytical skills Experience with downstream processing, such as dialysis, Tangential Flow Filtration (TFF), ultra-filtration and sterile filtration techniques.Experience with drug delivery and RNA are an asset.Familiarity with CRISPR technologies and therapeutic approaches Responsibilities:
Formulate and characterize lipid nanoparticle (LNPs) formulations both at small and intermediate scales.Follow SOPs and perform in-process and release analysis of manufacturing operations. Perform set-up and cleanup of equipment and manufacturing space.Assist team to generate LNP formulations for in-house and R&D requirements.Perform analysis of formulations using; UPLC-UV, UPLC-CAD, LC-MS, CGE, DLS, plate-based assays, gels, pH, osmolality, and endotoxin.Data analysis using statistical software's such as GraphPad PRISM, JMP etc.,Effectively collaborate within various groups and map out future needs and manage procurement of materials.Maintain detailed records of experimental protocols and data in electronic laboratory notebook.Additional duties and responsibilities as required will be assigned based on the needs of the team. ***Compensation within this range will be commensurate with level of experience***