Biochemist I

Job Description Summary
Job Description
We are
the makers of possible
BD is one of the largest global medical technology companies in the world. Advancing the world of health™ is our Purpose, and it's no small feat. It takes the imagination and passion of all of us—from design and engineering to the manufacturing and marketing of our billions of MedTech products per year—to look at the impossible and find transformative solutions that turn dreams into possibilities.
We believe that the human element, across our global teams, is what allows us to continually evolve. Join us and discover an environment in which you'll be supported to learn, grow and become your best self. Become a
maker of possible
with us.
Perform manufacturing activities in areas such as: purification, formulation, tissue culture or conjugation. Responsible for following established instructions for the execution of manufacturing production orders. Performs assays and tests following standard protocols. Provides cleaning, inspection, verification for calibration, troubleshooting and maintenance of equipment when needed. Participates in continuous improvement projects and initiatives. Ensures that work performed conforms to QSR, ISO and OSHA standards and regulations.
Tissue Culture Area Responsibilities:
Creates, maintains, and tests Master and Working cells Banks of antibody producing hybridomas.
Conducts in-process tests for viability, secretion and sterility.
Processes cell supernatant to remove debris and to concentrate product before purification, monitoring cell culturing process by various biochemical and immunologic procedures.
Purification Area Responsibilities:
Perform incoming testing for Culture Media, ascites fluids and materials that request evaluation using available purification techniques.
Test and purifies monoclonal antibodies from serum/ascites fluid and tissue culture supernatant by appropriate serum fractionation and/or column chromatographic techniques, and formulates monoclonal antibodies reagents.
Formulates purifies according finish goods specifications for concentration following dilution batch records.
Performs resin retest and reclaim process.
Conjugation Area Responsibilities:
Conjugates monoclonal antibodies from purified material using required molecules Fluorophore or dye of the molecules, monitoring conjugation process at several stages to increase yield and quality of conjugated antibodies.
Conjugates according finish goods specifications for concentration following dilution batch records.
Prepares malemaide and raw materials based on production plan requirements.
Maintains chromatography systems in order, including column packaging cleaning and equilibrations and report any breakdowns.
General Responsibilities
Provides in-process testing as required.
Completes materials movement transactions on SAP system and performs the required inventory control activities to maintain accuracy.
Maintains detailed production records.
Generates Quality Reports such as Out of Specification Reports, Deviations Reports, etc.
Initiates and participates in investigations following established quality assurance procedures and approved protocols, instructions etc.
Performs cleaning, inspection, verification for calibration and maintenance of equipment. Maintains related logs and records. Performs equipment troubleshooting.
Participates in the development and revision of Standard Operating Procedures (SOP's).
Participates in project related tasks as required.
Promotes a safe work environment. Provides recommendations on maintaining the safety of the work environment. Follows safety procedures. Participates in Environment Health and Safety (EH&S) programs. Initiates a corrective action whenever a hazard is identified. Notifies supervisor of all observed hazardous conditions or unsafe work practices.
Keeps abreast of the basic requirements for compliance in own area of work and follows those requirements. Participates as required in training on regulatory issues affecting own area of work. Brings regulatory compliance questions/issues to next level of management.
Actively participate in the Daily Management System by attending, leading shift start up meetings, and providing appropriate metrics
Participates in Continuous Improvement Projects related tasks as required.
Provide recommendations to support systems that continuously improve product/process quality and product availability, reduce cost, and increase production capability.
Maintain good housekeeping practices.
Performs other related duties and assignments as required.
Knowledge/Skills:
Knowledge of methods required to build, maintain and test Master and Working Cell Banks of antibody hybridomas.
Knowledge of the operation of related instrumentation such as Micropipettes and volumetric devices, Microscopes, Micro plate reader, CO2 Incubators, centrifuges and pipette and Biosafety Hoods.
Knowledge in the purification of monoclonal antibodies from serum/ascites fluid and tissue culture supernatant by appropriate serum fractionation and/or column chromatographic techniques.
Basic knowledge in chemicals and kinetic reactions.
FPLC (Fast Protein Liquid Chromatography), HPLC (High Pressure liquid Chromatography), UV monitors, chart recorders, electrophoresis and size exclusion columns knowledge preferable.
Knowledge in the formulation of reagents.
Knowledge of the operation of related instrumentation such Spectrophotometry and Centrifuges.
Knowledge of GMP, FDA, ISO and OSHA requirements highly desirable.
Knowledge of SAP highly desirable.
Solid understanding of MS Windows environment software such as MS Office.
Effective skills using analytical thinking, problem solving, interpersonal relationships, written and verbal communication, and planning/organization.
Demonstrated ability to follow established policies and procedures.
Fully Bilingual (English and Spanish).
Willing to travel to US mainland and offshore.
Education and Experience
Requires a Bachelors Degree in a related scientific field such as Chemistry, Biochemistry, Biology, Microbiology or Engineering.
A minimum of one year of experience in a laboratory or pharmaceutical/medical device/biotechnology environment or equivalent combination of related education and experience.
For certain roles at BD, employment is contingent upon the Company's receipt of sufficient proof that you are fully vaccinated against COVID-19. In some locations, testing for COVID-19 may be available and/or required. Consistent with BD's Workplace Accommodations Policy, requests for accommodation will be considered pursuant to applicable law.
Why Join Us?
A career at BD means being part of a team that values your opinions and contributions and that encourages you to bring your authentic self to work. It's also a place where we help each other be great, we do what's right, we hold each other accountable, and learn and improve every day.
To find purpose in the possibilities, we need people who can see the bigger picture, who understand the human story that underpins everything we do. We welcome people with the imagination and drive to help us reinvent the future of health. At BD, you'll discover a culture in which you can learn, grow, and thrive. And find satisfaction in doing your part to make the world a better place.
To learn more about BD visit https://bd.com/careers
Becton, Dickinson and Company is an Equal Opportunity/Affirmative Action Employer. We do not unlawfully discriminate on the basis of race, color, religion, age, sex, creed, national origin, ancestry, citizenship status, marital or domestic or civil union status, familial status, affectional or sexual orientation, gender identity or expression, genetics, disability, military eligibility or veteran status, or any other protected status.
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Primary Work Location
USA PR Cayey - Vicks Drive (BDB)
Additional Locations
Work Shift
US BD 2nd Shift 2pm-1030pm (United States of America)