Are you ready to take ownership of Gordian's unique in vivo screening platform, and drive the generation of transcriptomic data that is at the heart of our discovery efforts? You will be managing an interdisciplinary team of experts with a focus on operational excellence in executing screens, while finding ways for in vivo answers to improve both early and later stages of drug development for complex diseases. Gordian Biotechnology is a therapeutics company whose mission is to cure age-related diseases and ultimately allow people to lead longer, healthier lives.
Traditional ex vivo screening methods have failed to produce effective treatments, as age-related diseases have complex causes that include interactions with the aged environment. To address this problem, Gordian's platform is the first and only to enable pooled in vivo tests at scale in our proprietary "patient avatars". We are able to deliver and test hundreds of therapeutics in individual animals, and scale efficacy testing to cover every therapeutic target at the beginning of the drug discovery process. We can choose targets that really impact disease biology, to develop and commercialize therapies for the world's deadliest diseases, and eventually for the processes of aging itself.
About the Role: As Director of Genomics you will be responsible for the large perturbation datasets generated with Gordian's mosaic screening platform, allowing us to explore large swaths of disease biology and nominate new therapies. You will lead a single cell team recruited for their expertise and enthusiasm, ensuring continued operational excellence and efficiency of the team, helping organize and prioritize while balancing execution towards company goals.
An important part of your job is to solicit innovative ideas from the team and broader company, determine which efforts and initiatives are critical to achieving our next milestones, and provide structure for achieving these. You'll partner closely with our CSO to ensure there is a clear understanding on the current state of our platform and opportunities to evolve it as we move further down the development pipeline. Most of your team's work results in high-dimensional genomics data that requires analysis by our computational team to interpret.
Your Responsibilities: Organize the interface between data generation, data infrastructure and data analysis to communicate seamlessly and operate in lockstep.Monitor data quality and investigate oddities that could indicate issues with our screens.Set up systems to make screen data more accessible and ensure that computational outputs and context are fed back to your team.Implement improvements and strategy for the platform while continuing to execute at a high pace.Lead strategic operations between the single cell team and the data teams, refining communication and workflows.About You: You have a history of successful execution, both in- and outside of your job description. You want a chance to do your best work, immerse yourself and excel, alongside people who will inspire you and whom you'll be excited to spend your days with.
You have managed one or more teams collaborating in a fast-paced environment, and your team members will tell us that you brought out the best in them. You have worked at the intersection of molecules and computation and speak computational biology as a first or second language. You're familiar with single cell transcriptomic datasets and their challenges and have a solid analytical competency to help you troubleshoot odd results.
You have experience implementing strategy for strategic technology leadership in biotech (preferably in drug discovery) and setting the direction for a platform or suite of technologies. You're a crisp communicator, and are able to seamlessly manage collaboration with cross functional partners and teams.
You are excited to use cutting edge technology to find the best therapeutic targets, and turn those into drugs. You are familiar with pooled screening, barcoding, and the associated pitfalls and challenges, and ideally also with in vivo gene delivery and experimentation.
The Details: Gordian aims to provide everything you need to thrive. Beyond our community and science, you'll have enough equity to be a true stakeholder in the company, competitive salary, full health/dental/vision/life insurance, 401k with match, onsite lunch paid for 3 days a week, an onsite gym, whatever vacation you need to be at your peak, remote work flexibility, and access to world-class mentors and advisors to support your professional growth. Our building is in the heart of the biotech capital of South San Francisco.
$200,000 - $280,000 a year
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