Operations Manager - Next Generation Sequencing (Ngs) Core Lab (9610C) 31036

*Operations Manager - Next Generation Sequencing (NGS) Core Lab (9610C) 31036*
About Berkeley

At the University of California, Berkeley, we are committed to creating a community that fosters equity of experience and opportunity, and ensures that students, faculty, and staff of all backgrounds feel safe, welcome and included. Our culture of openness, freedom and belonging make it a special place for students, faculty and staff.

The University of California, Berkeley, is one of the world's leading institutions of higher education, distinguished by its combination of internationally recognized academic and research excellence; the transformative opportunity it provides to a large and diverse student body; its public mission and commitment to equity and social justice; and its roots in the California experience, animated by such values as innovation, questioning the status quo, and respect for the environment and nature. Since its founding in 1868, Berkeley has fueled a perpetual renaissance, generating unparalleled intellectual, economic and social value in California, the United States and the world.

We are looking for equity-minded applicants who represent the full diversity of California and who demonstrate a sensitivity to and understanding of the diverse academic, socioeconomic, cultural, disability, gender identity, sexual orientation, and ethnic backgrounds present in our community. When you join the team at Berkeley, you can expect to be part of an inclusive, innovative and equity-focused community that approaches higher education as a matter of social justice that requires broad collaboration among faculty, staff, students and community partners. In deciding whether to apply for a position at Berkeley, you are strongly encouraged to consider whether your values align with our [Guiding Values and Principles](https://apptrkr.com/get_redirect.php?id=2841025&targetURL=https://strategicplan.berkeley.edu/guiding-values-and-principles/), our [Principles of Community](https://apptrkr.com/get_redirect.php?id=2841025&targetURL=https://diversity.berkeley.edu/principles-community), and [our Strategic Plan](https://apptrkr.com/get_redirect.php?id=2841025&targetURL=https://strategicplan.berkeley.edu/)[.](https://apptrkr.com/get_redirect.php?id=2841025&targetURL=https://strategicplan.berkeley.edu)

Departmental Overview

The Innovative Genomics Institute (IGI) is a non-profit, academic research organization formed through the partnership of UC Berkeley and UC San Francisco, and located on the UC Berkeley campus. A key focus of the IGI is accelerating translation of CRISPR-based approaches to address real-world problems in human health, agriculture, and climate.

The IGI is committing to hiring researchers who want to work in a high-performing culture. The IGI is interested in candidates who will contribute to our commitment to excellence, diversity, and inclusion in academia. The IGI is also interested in individuals who may have had non-traditional career paths, taken time off for family/personal reasons, or excelled in careers outside academia.


Application Review Date

The First Review Date for this job is: 2/22/2022

Responsibilities

The NGS Core Lab Operations Manager will provide the scientific and technical expertise required to expand the IGI's Next Generation Sequencing (NGS) platform and to support all activities related to data generated by our NGS pipeline, from project design, optimization of library prep protocols, and running sequencing instruments, to primary sequencing data analysis and management.

Key Responsibilities:

Manage NGS Research & Development Projects

* Provide high quality practical advice to many R&D projects by applying broad NGS-related experimental and data analytics work experience and theoretical knowledge.
* Work on Clinical Phase 1 projects, such as Sickle Cell disease for CIRM (California Institute of Regenerative medicine).
* Preparing IND (Investigational New Drug) Application for Clinical Phase 2 projects.

Manage the NGS Core samples and library prep

* Oversee all samples are received, inventoried, stored, and processed
* Micro-pipetting, automation handling, creating, and designing detailed tracking systems.
* Specialist in NGS with starting material, complex extractions from cells, animal tissues, cell culture, etc.

Oversee and manage the Next Generation Sequencing pipeline

* Design and execute NGS for highly complex CRISPR validation experiments.
* Set up and perform complex sequencing experiments using multiple Illumina sequencers.
* Post-Sequencing data quality analysis.

Inventory, LIMS database, equipment, and operations management

* Manage all NGS Core operations, including instruments preventive maintenance, IQOQ, inventory purchasing and management, etc.
* Building LIMS (Laboratory Information Management Systems) and working with complex sequencing data information systems.

Consultation with Principal Investigators, post docs and staff

* Consult with users of the scientific community on bespoke library prep and sequencing reads.

Training and managing laboratory personnel

* Optimize, train, and support the IGI Clinical Laboratory COVIDSeq Assay.
* Hire, train & develop, and ongoing supervision of team members.
* Collaborate with HR to build job descriptions, hire staff, complete annual reviews, and participate in performance management.


Required Qualifications

* A strong understanding of NGS fundamentals and applications, critical factors influencing data quality, and an ability to troubleshoot the sequencing process end to end.
* Experience with NGS laboratory instrumentation, including liquid handling robots and automation of NGS library prep workflows.
* Demonstrated expertise in molecular biology wet lab skills including DNA extraction and purification, PCR and qPCR, DNA library preparation, QC, etc.
* Experience with genome editing using CRISPR/Cas9.
* Ability to conduct QA/QC experiments including, but not limited to, Agilent Bioanalyzer, Qubit Fluorospectrometer, qPCR.
* Data management, analysis and tracking using LIMS.
* NGS inventory management including sample intake handling and knowledge of Illumina kits/inventory specifications.
* Ability to train others in NGS laboratory techniques and operation.
* Highly organized and has outstanding time/operation management abilities, independence, and ability to manage self.
* Fast learner with a strong sense of urgency, a can-do attitude, and motivational skills to get the best out of team and co-workers. Loves and thrives in a fast paced and demanding academic environment.
* Ability to communicate with peers, Principal Investigators, and all levels of management.


Preferred Qualifications

* Experience with Illumina sequencing platforms (iSeq, MiSeq and NextSeq) and BaseSpace
* Experience with Salesforce LIMS platforms
* At least 5 years of experience with Next Generation Sequencing for highly complex CRISPR experiments
* Experience in academic research environment
* Previous experience with Clinical Phase 1 and Phase 2 trial and IND applications
* Familiarity with UCB standard processes, such as BearBuy, UC Path, and CalTime
* UCSPMC certificate

Education/Training:

* MS degree in molecular biology, biochemistry, biotechnology, or a closely related field, with relevant hands-on laboratory experience is preferred.


Salary & Benefits

Salary will be commensurate with experience.

To find the salary range for this position please visit: [https://tcs.ucop.edu/tcs/jsp/nonAcademicTitlesSearch.htm](https://apptrkr.com/get_redirect.php?id=2841025&targetURL=https://tcs.ucop.edu/tcs/jsp/nonAcademicTitlesSearch.htm). Use the numeric title code in the Job Posting (listed in parenthesis) to enter into the title code field on the TCS website. Click search and then click on the title code link for the Berkeley Campus (BKCMP).

To review salary placement guidelines by years of experience please visit: [https://hr.berkeley.edu/compensation-benefits/compensation/salary-and-pay/non-represented](https://apptrkr.com/get_redirect.php?id=2841025&targetURL=https://hr.berkeley.edu/compensation-benefits/compensation/salary-and-pay/non-represented).

For information on the comprehensive benefits package offered by the University visit:

[https://ucnet.universityofcalifornia.edu/compensation-and-benefits/index.html](https://apptrkr.com/get_redirect.php?id=2841025&targetURL=https://ucnet.universityofcalifornia.edu/compensation-and-benefits/index.html)




How to Apply

Please submit your cover letter and resume as a single attachment when applying. Please upload the document in the Resume section, then skip the (optional) Cover Letter upload section.

Equal Employment Opportunity

The University of California is an Equal Opportunity/Affirmative Action Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, or protected veteran status. For more information about your rights as an applicant see:

[https://www.eeoc.gov/sites/default/files/migrated_files/employers/poster_screen_reader_optimized.pdf](https://apptrkr.com/get_redirect.php?id=2841025&targetURL=https://www.eeoc.gov/sites/default/files/migrated_files/employers/poster_screen_reader_optimized.pdf)
For the complete University of California nondiscrimination and affirmative action policy see:
[http://policy.ucop.edu/doc/4000376/NondiscrimAffirmAct](https://apptrkr.com/get_redirect.php?id=2841025&targetURL=http://policy.ucop.edu/doc/4000376/NondiscrimAffirmAct)





*To apply, visit [https://careerspub.universityofcalifornia.edu/psp/ucb/EMPLOYEE/HRMS/c/HRS_HRAM.HRS_APP_SCHJOB.GBL?Page=HRS_APP_JBPST&Action=U&FOCUS=Applicant&SiteId=21&JobOpeningId=31036&PostingSeq=1](https://apptrkr.com/2841025)*












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