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Job DescriptionAbout the role: At Takeda, we are a forward-looking, world-class R&D organization that unlocks innovation and delivers transformative therapies to patients. By focusing R&D efforts on three therapeutic areas and other targeted investments, we push the boundaries of what is possible in order to bring life-changing therapies to patients worldwide.
Are you looking for a patient-focused, innovation-driven company that will inspire you and empower you to shine? Join us as a PK/PD and QSP modeler, Neuroscience – Senior Scientist in our Cambridge, MA location.
Objective / Purpose: As a PK/PD and QSP modeler, Neuroscience – Senior Scientist in DMPK & Modeling, you will be empowered to interface between biology/pharmacology, chemistry/biologics, nonclinical safety assessment, drug metabolism, translational medicine, clinical pharmacology and clinical research, to influence drug discovery and development.
How you will contribute: ACCOUNTABILITIES Drive decision-making in drug discovery research by building a quantitative model of novel therapeutic agents to treat various neurological diseases including neurodegeneration and neuromuscular diseases.Work on cross-functional teams with preclinical biology/pharmacology, chemistry/biologics, nonclinical safety assessment, translational medicine, clinical pharmacology and clinical research to develop a quantitative model-based understanding of the interactions of target biological pathways and novel therapeutic agents, and their impact on disease progression.Formulate and implement team-engaged right modeling & simulation strategy. Design and build translational PK/PD/efficacy and mechanistic and/or systems models to assist and accelerate decisions around drug candidate selection, study design optimization as well as biomarker selection.Enable translational predictions of human pharmacologically active/efficacious dose, dosing schedule and safety margin for clinical trials. Leverage clinical benchmarking insights from clinical comparators and/or their reverse translation.Minimum Requirements/Qualifications: MS/PhD/PharmD in chemical or biomedical engineering, pharmaceutical sciences, mathematics, physics, or equivalent area.Strong competency in building mathematical models is required (in commonly used languages such as MATLAB, SimBiology, NONMEM, Phoenix, Python, or R)At least 2 years (8 years with MS) of industry experience in mathematical modeling of biological systems.Demonstrated strong analytical skills to evaluate complex information and identify key scientific questions.Ability to communicate complex modeling results clearly and concisely to cross-functional audience is critical.Background or interest in applying modeling and simulation approaches to neurological diseases is preferred.This position is currently classified as "hybrid" in accordance with Takeda's Hybrid and Remote Work policy.
Takeda Compensation and Benefits Summary We understand compensation is an important factor as you consider the next step in your career. We are committed to equitable pay for all employees, and we strive to be more transparent with our pay practices.
For Location: Boston, MA
U.S. Base Salary Range: $133,000.00 - $209,000.00
The estimated salary range reflects an anticipated range for this position. The actual base salary offered may depend on a variety of factors, including the qualifications of the individual applicant for the position, years of relevant experience, specific and unique skills, level of education attained, certifications or other professional licenses held, and the location in which the applicant lives and/or from which they will be performing the job. The actual base salary offered will be in accordance with state or local minimum wage requirements for the job location.
U.S. based employees may be eligible for short-term and/or long-term incentives. U.S. based employees may be eligible to participate in medical, dental, vision insurance, a 401(k) plan and company match, short-term and long-term disability coverage, basic life insurance, a tuition reimbursement program, paid volunteer time off, company holidays, and well-being benefits, among others. U.S. based employees are also eligible to receive, per calendar year, up to 80 hours of sick time, and new hires are eligible to accrue up to 120 hours of paid vacation.
EEO Statement Takeda is proud in its commitment to creating a diverse workforce and providing equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, gender expression, parental status, national origin, age, disability, citizenship status, genetic information or characteristics, marital status, status as a Vietnam era veteran, special disabled veteran, or other protected veteran in accordance with applicable federal, state and local laws, and any other characteristic protected by law. LocationsBoston, MA
Worker TypeEmployee
Worker Sub-TypeRegular
Time TypeFull time
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