Principal Scientist/Associate Director, Protein Engineering

Open positionsLocation: Boston, MA

Job Id: R096-R2

# of Openings: 1

We seek an energetic and motivated Principal Scientist or Associate Director to lead the design and execution of strategies to engineer hematopoietic stem cells by a combination of genetic and protein engineering approaches.
You will join a team of scientists dedicated to moving a novel gene therapy drug candidate into the clinic. Join us and be part of building a company revolutionizing the reach and access of the curative power of genomic medicines for patients with serious diseases.
Responsibilities: Lead the design and testing of fusion proteins and antibodies in different formats to optimize their function.Lead therapeutic antibody selection, design, and optimization for antibody discovery programs.Oversee the development of assays to screen and test the function and affinity of antibodies and recombinant proteins.Manage CROs in development and characterization of therapeutic antibodies, developing and guiding the research plan and ensuring timely delivery of data.Qualifications: Required:
A Doctoral Degree in biochemistry, molecular biology or related field with a minimum of eight years of experience in the biotechnology/pharmaceutical industry and/or an academic setting (industry experience is preferred).Demonstrated expertise applying molecular biology and protein engineering approaches to optimize the function of antibodies and other proteins.Proficiency in molecular biology techniques.Experience expressing proteins in mammalian cells.Experience developing and implementing functional and affinity assays to characterize antibodies.Hands-on experience using display approaches to select and screen novel therapeutic antibodies.
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