Job Description - Sr. Research Scientist, Cancer Center (Slabicki Lab) (3308002)
Sr. Research Scientist, Cancer Center (Slabicki Lab) - (3308002)
The principal duties of this role are to assist in experiments for research projects under the supervision of the PI of the laboratory. Specifically, the lab is part of the Krantz Family Center for Cancer Research, and the focus is on targeted protein degradation.
The Slabicki Laboratory is dedicated to expanding the druggable proteome by employing functional genomics and targeted protein degradation. We have extensive experience in functional genomic approaches, cell biology, bioinformatics, molecular biology, and biochemistry. Our two main areas of investigation are characterizing novel derivatives of thalidomide in order to re-deploy them for new indications and identifying novel E3 ubiquitin ligase – substrate interactions to facilitate therapeutic efforts for targeted degradation. Our current research has the potential to expand the repertoire of E3 ligases susceptible to degradation with small molecules.
Responsibilities:Design, plan, and conduct experiments leading to identify E3 ligases modulating selected cancer dependencies.Innovate, plan, and conduct experiments in controlled laboratory settings to expand scientific knowledge.Record data, analyze key findings, and share their research with the scientific community.Be involved in applying for external research funding.As this is a senior role, a doctorate degree is required.
Key Skills:Critical thinking for analyzing data and forming conclusions.Attention to detail for accuracy.Proficiency in data collection, organization, and analysis.Effective communication for team coordination.Understanding of statistics for data interpretation.Expertise in experimental design for hypothesis testing.Molecular biology techniques to improve research proficiency and competitiveness.Molecular Biology Techniques Required:Polymerase Chain Reaction (PCR)Gel electrophoresisDNA extractionWestern blottingCell cultureRNA isolationGene cloningProtein expressionDNA sequencingTransfection, CRISPR screening, and Next Generation SequencingMassachusetts General Hospital is an Affirmative Action Employer. By embracing diverse skills, perspectives, and ideas, we choose to lead. All qualified applicants will receive consideration for employment without regard to race, color, religious creed, national origin, sex, age, gender identity, disability, sexual orientation, military service, genetic information, and/or other status protected under law. We will ensure that all individuals with a disability are provided a reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment.
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